Targeting the “energy crisis” in fat cells can fight the effects of obesity

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The interaction between obesity and its many complications, such as type 2 diabetes, is complex and may include factors such as inflammation and insulin resistance. A better understanding of this relationship may reveal new ways to prevent adverse health effects faced by overweight subjects, and a new study has identified a new target that compares to an “energy crisis” in fat cells.

The onset of obesity can adversely affect the body many waysfor example, there is an increased risk of developing type 2 diabetes, cardiovascular disease and many cancers, and how this disease directly affects cells is thought to play an important intermediate role. This new study, conducted by scientists from the Royal Institute of Sweden, tried to better understand what causes inflammation of adipose tissue in obese people, the mechanisms of which remain largely unclear to this day.

They began by analyzing adipose tissue from clinical cohorts and found that the way cells metabolized phosphocreatine and creatine was altered, seemingly as a result of weight gain. In human cells and in living mice, the team showed that this causes fat cells to go into an “energy crisis,” and instead they combine glucose.

“We believe that disruption of creatine metabolism in fat cells leads to an‘ energy crisis ’that forces the body to compensate for it by increasing glucose utilization,” said Dr. Salvan McDasi, one of the first authors of the study. “It stimulates genes that lead to chronic inflammation in the body with an increased risk of insulin resistance.”

Although the driving forces of adipose tissue inflammation and dysfunction in a broader sense remained unknown, scientists had previously focused on the role of immune cells, but potential treatments have not yielded any promising results in these experiments. The authors of this new study believe that such efforts may be better targeted to fat cells.

Reducing inflammation in fat cells and minimizing the risk of insulin resistance may prove to be a valuable intervention in the treatment of obesity. Insulin resistance means a violation of the body’s cells’ ability to respond to insulin, which means that they cannot easily absorb glucose from the blood. Thus, it is a major risk factor for type 2 diabetes, affecting about 30 million people in the United States alone, and others advanced research focused on combating insulin resistance as a preventative measure.

For its authors, the results of a new study represent “unexpected” new ways to combat adipose tissue dysfunction, and they have some ideas on where to look next.

“To determine the causes of adipose tissue inflammation, the next step is to study how the regulation of enzymes that control creatine metabolism in the body leads to altered glucose utilization,” said Simon Lecuthre, the study’s second lead author. study.

The study is published in the journal The nature of metabolism.

Source: Carolingian Institute



Targeting the “energy crisis” in fat cells can fight the effects of obesity

Source link Targeting the “energy crisis” in fat cells can fight the effects of obesity